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Avanços do conhecimento sobre efeitos de antigas exposições com aspectos interessantes inclusive de efeitos protetores de exposição associada a manganês.
E aqui na terra Brasilis, como está essa situação?
Destaque na Environmental Health Perspectives
Invited Perspective:Toxic Metals and Hypertensive Disorders of Pregnancy
Vejam parágrafos iniciais
The worldwide prevalence of gestational hypertension and preeclampsia is estimated at 10% and 2%–8%, respectively.1 In the United States alone, the incidence of preeclampsia—a leading cause of maternal mortality—increased by 25% between 1987 and 2004.2 Despite the prevalence and severity of these conditions, definitive causes remain elusive, hindering risk reduction interventions.3 There has been increasing attention to the role of environmental chemicals, including toxic metals, in the development of gestational hypertension and preeclampsia (together termed hypertensive disorders of pregnancy).4,5 The recent study by Borghese et al. significantly contributes to the growing literature establishing associations between toxic metal exposure and these disorders.6
The authors examined mixture effects, highlighted modification of toxic metal effects by essential metals, evaluated exposure windows of susceptibility, measured various species of toxic metals (e.g., arsenic), and assessed confounding by seafood consumption and air pollution, all within one of the largest study populations to address this topic. They found an increased risk of preeclampsia with elevated third-trimester blood lead levels. They also observed an increased risk of preeclampsia and gestational hypertension with elevated first-trimester blood arsenic concentrations. These data underscore arsenic and lead as perinatal toxicants that remain an urgent public health concern. Lead has been previously found to increase the risk of preeclampsia7; however, there is more mixed evidence with regard to arsenic’s contribution to hypertensive disorders of pregnancy.4 The findings by Borghese et al. expand upon prior work that has also documented other metals of concern, including cadmium, as potential etiologic factors underlying hypertensive disorders of pregnancy.
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