Tema emergente:
CNN divulga artigo - cujo resumo é apresentado mais abaixo destacando efeitos de PFAS na densidade óssea de adolescentes e abrindo dúvidas sobre outros efeitos em adultos. Será que esses achados podem estar relacionados com risocs de fraturas e ou osteoporose de aparecimento precoce na vida adulta?
O artigo da CNN foi "Potentially toxic ‘forever chemicals’ may harm kids during critical period for bone development". Vejam o link.
https://edition.cnn.com/2026/03/17/health/pfas-low-bone-density-kids-we…
O artigo no Journal of the Endocrine Society é
Per- and polyfluoroalkyl substances and adolescent bone mineral density: assessing periods of susceptibility Open Access
Jessie P Buckley , et al
Journal of the Endocrine Society, Volume 10, Issue 4, April 2026, bvag039, https://doi.org/10.1210/jendso/bvag039
Abstract
Context
Per- and polyfluoroalkyl substances (PFAS) may affect adolescent bone mineral density (BMD), but few studies have examined periods of susceptibility.
Objective
To assess associations of repeated serum PFAS concentrations with early adolescent BMD.
Methods
Among 218 children in a prospective pregnancy and birth cohort, we quantified serum concentrations of perfluorohexane sulfonic acid (PFHxS), perfluoroctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) at delivery (cord) and ages 3, 8, and 12 years. We measured BMD at 6 skeletal sites using dual-energy X-ray absorptiometry at age 12 years. We estimated covariate-adjusted differences and 95% confidence intervals (CIs) in BMD Z-scores per interquartile range (IQR) increase in each PFAS at each time point using multiple informant linear regression models.
Results
Higher PFOA concentrations were associated with lower 1/3 distal radius BMD at every time point: delivery (β: −0.39; 95% CI: −0.69, −0.10), 3 years (β: −0.36; 95% CI: −0.86, 0.14), 8 years (β: −0.54; 95% CI: −0.91, −0.16), and 12 years (β: −0.40; 95% CI: −0.75, −0.04). Higher 3-year PFHxS and PFOS concentrations were significantly associated with higher whole body, total hip, and femoral neck BMD Z-scores, while higher 12-year PFNA concentrations were associated with lower BMD Z-scores. Associations of 12-year PFAS with lower 1/3 distal radius BMD were stronger among females than males.
Conclusion
Serum PFOA concentrations from delivery to age 12 years were associated with lower 1/3 distal radius BMD in early adolescence, while associations of other PFAS with BMD varied by exposure assessment time point, skeletal site, and sex.
perfluoroalkyl substances, adolescent health, bone mineral density, susceptibility, critical periods, mixtures
SubjectEndocrine Disrupting Chemicals
Issue Section:Clinical Research Article
Collection: Endocrine Society Journals
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