Sugestão de leitura recebida da Professora Edith Seligmann Silva
A pandemia encarada como desafio em múltiplas frentes.
Antibody correlates of protection from SARS-CoV-2 reinfection prior to
vaccination: A nested case-control within the SIREN study
Ana Atti a , ∗, Ferdinando Insalata a , Edward J Carr b , Ashley D Otter c , Javier Castillo-Olivares d , et al
Summary:
Objectives: To investigate serological differences between SARS-CoV-2 reinfection cases and contemporary controls, to identify antibody correlates of protection against reinfection.
Methods: We performed a case-control study, comparing reinfection cases with singly infected individuals pre-vaccination, matched by gender, age, region and timing of first infection. Serum samples were tested for anti-SARS-CoV-2 spike (anti-S), anti-SARS-CoV-2 nucleocapsid (anti-N), live virus microneutralisation (LV-N) and pseudovirus microneutralisation (PV-N).
Results were analysed using fixed effect linear regression and fitted into conditional logistic regression models. Results: We identified 23 cases and 92 controls. First infections occurred before November 2020; reinfections
occurred before February 2021, pre-vaccination. Anti-S levels, LV-N and PV-N titres were significantly lower among cases; no difference was found for anti-N levels. Increasing anti-S levels were associated with reduced risk of reinfection (OR 0 ·63, CI 0 ·47-0 ·85), but no association for anti-N levels
(OR 0 ·88, CI 0 ·73-1 ·05). Titres > 40 were correlated with protection against reinfection for LV-N Wuhan (OR 0 ·02, CI 0 ·001–0 ·31) and LV-N Alpha (OR 0 ·07, CI 0 ·009–0 ·62). For PV-N, titres > 100 were associated
with protection against Wuhan (OR 0 ·14, CI 0 ·03–0 ·64) and Alpha (0 ·06, CI 0 ·008–0 ·40).
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